General Information

  • ID:  hor001396
  • Uniprot ID:  Q5U900
  • Protein name:  FRF3/5
  • Gene name:  NA
  • Organism:  Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
  • Family:  FMRFamide related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GGSLFRF
  • Length:  7
  • Propeptide:  MEHISLAMVLAFLTALICTAHSDDGAHSSSVKAFESSNHESHQPQKRSPSASPSAYDEDLLLADSGLMDAPYNLDDVDKRNTLFRFGKRQGSLFRFGKRGGSLFRFGKRGTLLRFGKRGGSLFRFGRSGPSDSSDSENMEDKRTLFRFGKRSDLDLLRDALAEAEYSNLPVYAENEPMKRDIQGFHWGMDNDEQ
  • Signal peptide:  MEHISLAMVLAFLTALICTAHS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  inhibit LGCs and CDCs to suppress host metabolism and reproduction.
  • Mechanism:  Activate the K + current in cells
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 2.2*10(-6)m
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5U900-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001396_AF2.pdbhor001396_ESM.pdb

Physical Information

Mass: 89009 Formula: C37H54N10O9
Absent amino acids: ACDEHIKMNPQTVWY Common amino acids: FG
pI: 10.55 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: 47.14 Boman Index: -556
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 55.71
Instability Index: 2620 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  15715658
  • Title:  LFRFamides: A Novel Family of Parasitation-Induced -RFamide Neuropeptides That Inhibit the Activity of Neuroendocrine Cells in Lymnaea Stagnalis